In 2020, we will also hopefully hear news about another c-Abl inhibitor called Radotinib, which is being developed by South Korean firm Ilyang Pharmaceutical. It is always a good meeting – focused on explaining the research in plain English – and this year has a fastastic line up of speakers (I’m just second or third fiddle). The companies have developed BIIB094 – an antisense oligonucleotide targetting LRRK2. Special thanks to Dr Prakash K. Good services from the F and B team. The immunotherapy approach uses antibodies, which are Y-shaped proteins that act like alert flags for the immune system. One example of this is a drug called NPT088, which is being developed by Proclara Biosciences. Here at Poseidonia Healthcare, we offer a full range of treatments for Parkinson’s Disease with no adverse side affects you normally get from Pharmaceutical medications, and we have been successful in delaying the onset of progressive symptoms. Significant improvement with this medication will often confirm your diagnosis of Parkinsons Disease. While some of the information discussed in this post may cause concern, please speak with your medical physician before attempting any change in an existing treatment regime. | The Science of Parkinson's, The Aspirations of Aspen | The Science of Parkinson's, Ptbp1: “One and done”(?) These are vaccines for Parkinson’s, which targets the toxic form of alpha synuclein. Traditionally, the cell transplantation procedure for Parkinson’s has involved multiple injections of developing dopamine neurons being made into an area of the brain called the putamen (which is where much of the dopamine naturally produced in the brain is actually released). Antibodies target very specific structures, while ignoring everything else. Researchers have targeted this protein as a means of slowing/halting Parkinson’s. The treatment result depends on the disease, patient’s condition, the number of treatment procedures, etc. These brown areas are the dopamine producing cells (stained in brown). This biotech firm uses a degradation tag (dTAG) for targeting pathogenic proteins that need to be disposed of (Click here to read recent research about this). Parkinsons Disease signs and symptoms can be different for everyone. Cell transplantation currently represents the most straight forward method of cell replacement therapy. They found that neurons derived from … The 14th Annual PD Therapeutics Conference was scheduled to be held on October 8, 2020, in New York. Another company Oxyrane was awarded a grant from the Michael J. Continuous progress is being made towards cell replacement therapies for Parkinson’s. This also is significant to reduce the speed of further advance of the illness. There is an ongoing European clinical trial called Transeuro which is using the fetal cell approach for Parkinson’s. If determined to be safe, it could be interesting to further explore the idea of RIPK1 inhibition in Parkinson’s (particularly if upstream LRRK2 inhibition is difficult to tolerate long-term – no evidence of this to date though). Ozone Therapy is effective for both activation of the cerebral microcirculation and increasing energy production by neurons, as recent studies have shown. And it should certainly not be assumed that any of the treatments mentioned below are going to be silver bullets or magical elixirs that are going to “cure” the condition. They are currently conducting a Phase I safety/tolerability trial of UB-312 in healthy volunteers and in participants with Parkinson’s. One inflammation-related biotech company that we are watching in 2020 is Inmune Bio. The study is published June 24, 2020 in Nature. It will be interesting to see how things develop in 2020. But there is evidence that this drug can increase the levels of the GBA protein (Glucocerebrosidase) in models of Parkinson’s (Click here to read a SoPD post on this). Researchers also recognize that, as the disease presents so differently in each patient, there may not be a single "cure" for Parkinson's disease. A topic of great interest to many readers of the SoPD has been the sweetner Mannitol, which – after some interesting preclinical results – was crowd sourced into a patient-led online study by a group called Clinicrowd. Founded in 2016, perhaps in 2020 we will learn about what they have been up to with regards to misfolded proteins. And by limiting the build up of proteins – like alpha synuclein – these experimental therapies may help to slow down the progression of Parkinson’s. Another compound that has exhibited interesting results in ALS is CuATSM which is being developed by Collaborative Medicinal Development Pty (Click here to read more about the ALS result). The issue with ENT-01 compared to other molecules targeting alpha synuclein is that it does not cross the blood brain barrier. Precinical data suggests the treatment has mitochondrial benefits in models of Parkinson’s, which led to the development of the “UP” study (“UDCA in Parkinson’s” study – Click here to read a SoPD post on the topic). Ability to walk for longer distances One of the methods employs nanobodies derived from alpaca llamas. Parkinson’s breakthrough: ‘Accidental discovery’ paves way to find a CURE for disease June 29, 2020 Scientific breakthroughs sometimes occur … Despite the set back with this GDNF trial, there is another GDNF trial that is investigating a gene therapy form of GDNF. This meeting “will focus on the origins and development of Parkinson’s, from potential triggers through the early symptoms and stages of the disease“. Participants will be randomly assigned to one of three groups (1500 mg or 4500 mg of Prasinezumab, or placebo treatment). Reduced involuntary movements This gold-derived (seriously) treatment acts as a potent anti-oxidant, but it also boosts the energy production in mitochondria (Click here to read an SoPD post about this research). Very interesting. The participants in the study will be followed and assessed for 2 years post transplantation. And late last year, Genentech, a subsidiary of Swiss pharma giant Roche, bought up Jecure Therapeutics – a biotech firm with a portfolio of preclinical NLRP3 inhibitors aimed at various inflammatory conditions (it is fair to say that this biotech was primarily looking at liver inflammation, but perhaps a neuro-focused pharma like Roche will also explore potential neurodegenerative applications). The body’s immune system can be encouraged to develop its own antibodies that target the toxic form of alpha synuclein (using, Researchers can design antibodies themselves that specifically target the toxic form of alpha synuclein (while leaving the normal version of the protein alone), and then inject those antibodies into the body (. "It would address symptomatic relief." A dose escalation study to determine safety in early-stage GBA-associated Parkinson’s. Did he want an exact date?!? Once enough antibodies bind to a particular object, the immune system will dispose of it. This process is called ‘Parthenogenesis’, and it’s not actually as crazy as it sounds as it occurs naturally in some plants and animals (Click here to read more about this). https://youtu.be/VdKIRqkMOtI . 47a Eleftherias Avenue In 2019, a new GLP-1R agonist called NLY01 entered the clinical trial process. It is gradually being agreed that rather than being a single ‘disease’, Parkinson’s may actually be a ‘syndrome’ – that is, a collection of conditions that share similar symptoms. Information provided by Kyoto University (Click here for the study website) and the Japanese media has indicated that this Phase I/II clinical trial aims to investigate the safety and efficacy of transplanting human IPS cell-derived dopaminergic progenitors into the brains of people with Parkinson’s (what stage of PD has not been disclosed). The early signs may be barely noticeable. ( Log Out /  Kind regards, In addition to these two fetal cell transplantation studies, there are currently 4 ongoing stem cell-based clinical trials for Parkinson’s. This therapy, however, is rarely covered by health insurance. PARKIN is a protein that has many functions, and disruption of it is associated with increased risk of developing Parkinson’s. It is still early days for Navitor, but one to watch perhaps. But the order in which these develop and their severity is different for each individual. Antisense oligonucleotides are a method of inhibiting RNA rather than proteins – this means that this drug blocks LRRK2 RNA rather than the subsequent protein (Click here to read a previous SoPD post about this approach). This means that the actually benefits of the transplantation technique will not be apparent for some time (2-3 years on average). The meeting will be held on the 24th October at the Link Hotel Loughborough. The second Deferiprone study is scheduled to finish in 2020 (Source). Lord Robert Baden-Powell. Emergency Helpline: This is a Phase II clinical trial of an alpha synuclein targeting immunotherapy (called Prasinezumab – formerly called RO7046015 & PRX002) being conducted by the pharmaceutical company Roche and biotech firm Prothena Biosciences. By tagging the alpha synuclein as it is being passed from one cell to another, and allowing the immune system to remove it, researchers hope to slow down the progression of Parkinson’s. This Parkinsons breakthrough can now be easily taken as a proven, glutathione-building natural supplement. Your doctor may suggest you work with a physical therapist to learn an exercise program that works for you. We will be hosting the 2020 Parkinson’s UK Research Conference as an entirely online, CPD accredited, meeting. *Patient feedback, articles and testimonials provided on this site are for informational purposes only and should not be considered as a guaranteed result for every case of illness. Our mission is to obliterate Parkinson's once and for all. Rejuvenation effects will be noticed within 10 days of having received the treatment. Fox Foundation in 2018 to develop an “Innovative Glucocerebrosidase enzyme therapy as a disease-modifying systemic treatment for Parkinson’s disease” (Click here to read more about this). Now, if one of these ‘direct’ or ‘indirect’ approaches is able to slow or halt Parkinson’s, the next requirement in a ‘curative therapy’ for Parkinson’s is: Once a drug or a treatment has been determined to slow down the progression of Parkinson’s, it will be necessary to protect the remaining cells and provide a nurturing environment for the third part of the ‘cure’ (Cell replacement therapy – more on that below). Another company that is developing TORC1 inhibitors is Navitor Pharmaceuticals. One of these studies was in Alzheimer’s and the other was in motor neurone disease (or ALS), and both were scheduled to complete in late 2019 (Click here and here to read more about these studies). BlueRock is a stem-cell therapy company focused on induced pluripotent stem cell (iPSC)-derived therapeutics for cardiovascular disease and neurodegenerative disorders, particularly Parkinson’s (co-founders Lorenz Studer and Viviane Tabar are world renowned experts in the field of cell transplantation for Parkinson’s). I am also to date naive of rasagiline etc Ting Sun, Zhe-Xu Ding, Xin Luo, Qing-Shan Liu, Yong Cheng, Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease, Oxidative Medicine and Cellular Longevity, 10.1155/2020/3807476, 2020, (1-14), (2020). Specifically, the researchers will be transplanting human parthenogenetic stem cells-derived neural stem cells (hpNSC). Most are still in preclinical development, but worthy of mention here in order to provide a broad view of the different approaches being taken to tackle Parkinson’s. Source: Intechopen. A future treatment for Parkinson’s? Although the trials are inevitably of a jam tomorrow nature I am reassured that my DIY “Amazon regime” might be on the right track of slowiing progression ( of iPD in a 74 yrs male). | The Science of Parkinson's, Follow The Science of Parkinson's on WordPress.com, The drug development pipeline for Parkinson’s. But these immunotherapy trials will have limited ability to actually affect alpha synuclein within cells (remember, they are tagging and grabbing the protein as it is being passed between cells). Drug companies have employed vast resources in this area in the hope of discovering a treatment which will work across conditions (think Alzheimer’s, Parkinson’s, Huntington’s, etc), and thus provide them with tremendous profits. VitK2Mk4Mk7 ; directs extra calcium uptake caused by D3 to bones Axovant Will be announcing the progress from their trial in H1. Your arms may not swing when you walk. OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING GBA: One interesting GBA-related development from 2019 was a research report in October, highlighting a new small-molecule modulator of glucocerebrosidase (the GBA protein). In 2017, the researchers behind this trial published a report evaluating their IPS cells in primate models of Parkinson’s (Click here to read more about that research report). And we will now explore what is happening in each of these components and discuss what is scheduled for 2020 (I have underlined “finished in 2020” where a trial is completing this year – there are quite a few!). By Divya Ramaswamy @Dreamfaktry 06/30/20 AT 6:55 AM. There are whispers in the wind that Phase I testing is underway, but we are waiting for confirmation of this from the company. One of the acknowledged limitation of the immunotherapy approaches, is the low amount of antibody actually accessing the brain. Simon. Your doctor may order lab tests, such as blood tests, to rule out other conditions that may be causing your symptoms. This situation has led a growing number of biotech companies to develop small molecules that can enter and target alpha synuclein inside of cells. But it would be positive to see a larger, double blind, placebo controlled study started in 2020. Observations Diagnosis of Parkinson disease is based on history and examination. In 2020, I will be curious to see if companies like Fujifilm/Cellular Dynamics or Novo Nordisk step up to the plate and start a clinical trial program focused on cell transplantation for Parkinson’s. This is a larger trial than the SKY study, with 330+ participants who are being treated with either Deferiprone or a placebo treatment for 9 months (Click here to read more about this). Researchers published data suggesting that terazosin could rescue models of Parkinson’s by boosting energy production in mitochondria. IND in 2020?!? In addition, there is evidence that the drug also blocks the aggregation of alpha synuclein and has beneficial effects in models of Parkinson’s (Click here to read an example). In 2019, another Korean pharmaceutical company Dong-A ST Co was scheduled to complete a Phase II clinical trial of DA-9805 in people with Parkinson’s (Click here to read more about this trial). Set up by a group of ex-Genentech scientists, Denali is already clinically testing two LRRK2 inhibitors: involved with multiple cellualr pathways leading to inflammation or cell death. Reach out to us for further information or a free consultation with regards to your specific issues and needs. In 2020, we will be hoping to hear news about the development of the alpha synuclein-targeting PROTAC. This study (called the SKY study) recruited 140 people with early Parkinson’s and treated them twice-daily for 9 months with Deferiprone (one of 4 different doses) or a placebo drug (Click here to read more about the details of this study). We were thrilled to still be able to host the 2020 Tom Isaacs Charity Golf Day this year. ‘Rallying’ (as it is affectionately known) has one simple aim: to involve people living with Parkinson’s in research. Similarly, Casma Therapeutics is developing drugs that activate the calcium channel TRPML1 to promote autophagy. Fingers crossed for 2020. Much progress is expected in the gene therapy sphere too in 2020. Supportive therapies can help ease some of the symptoms and complications of Parkinson's disease, such as pain, fatigue and depression. Thank you to everyone who generously donates to Drive Away Parkinsons for Parkinson's Research. Does Parkinson’s have us by the short and curli? WEDNESDAY, May 13, 2020 (HealthDay News) -- In a first, scientists have treated a Parkinson's disease patient with his own skin cells -- repurposing them to … These two companies have two additional alpha synuclein-targeting immunotherapy treatments called PD1601 & PD1602 which are also in development. The Stem Cell Therapy cost is at a price that most people can overcome. A lot of excitement in Voyager AADC considering the RMAT designation, Hi Deepak, Parkinsons Disease is a progressive nervous system disorder that affects movement. Your speech may become soft or slurred. Postmortem analysis – of the brains of individuals who have previously received transplants of dopamine neurons and then subsequently died from natural causes – has revealed that the transplanted cells can survive the surgical procedure and integrate into the host brain. (The Cure Parkinson’s Trust is a supporter of the Simvastatin study). Click here to subscribe to the Parkinson’s News Today Newsletter! By Dan Robinson 18 Feb 2020. And there is evidence for involvement of RIPK1 in Parkinson’s (, Interestingly, in early 2019 Denali and the pharma company Sanofi initiated two Phase I clinical trials of their RIPK1 inhibitor, DNL747. A second company developing a vaccine against alpha synuclein is United Neuroscience‘s (UB-312). You must be given a sufficient dose to show the benefit, as low doses for a day or two aren’t reliable. Congratulating the Aster management for taking forward such a great venture. There’s no cure, but Ayurvedic treatments can help to arrest the degeneration of brain cells enhancing the fine and gross motor movements. Part 1 of the Pasadena study was scheduled to complete in December 2019, with Part 2 finishing in February 2021. A large Phase III clinical trial of the effects of Lingzhi (also known as Ganoderma or reishi in Japan) on disease progression in 288 people with recently diagnosed, untreated Parkinson’s is scheduled to finish in late 2020 (Click here to read more about this study). And until we have developed methods that can identify Parkinson’s long before the motor features appear (which would require only a disease halting treatment), some form of cell replacement therapy is required to introduce new cells to take up lost function. Many of the symptoms are due to a loss of neurons that produce a chemical messenger in your brain called dopamine. This biotech company is focused on developing a novel class of vaccines that are fully synthetic (they call them ‘endobody vaccines‘) and can train the body to treat/prevent neurological condtions. We’re not even half way yet. The ISCO trial involves 12 participants who have been evaluated over 12 months in this evaluation of safety and tolerability. Tweet. Share. This is a phase II, 52 week trial of Ambroxol in 75 people with Parkinson’s Disease Dementia (Click here to read more about this trial). In 2018, Alterity Therapeutics (formerly PRANA Biotechnology) initiated a clinical trial of their drug PBT434 in healthy individuals. In 2019, researchers reported that a failure to effectively remove Miro1 was apparent in a large proportion of cells collected from both people with Parkinson’s and those at high risk of developing the condition – raising the possibility of a potential biomarker. When dopamine levels decrease, it causes abnormal brain activity, leading to symptoms of Parkinsons Disease. So it would be pleasing to hear news regarding the development of trodusquemine (and perhaps the initiation of a Phase I clinical trial) in 2020. Anti-inflammatory: vit D3 Fox Foundation and The Silverstein Foundation funded them in early 2019 (, t will also be interesting to learn more about. A randomised, double blind study of efficacy of. You can do whatever you like with it! Most of the Parkinson’s Disease Patients treated with the combination of Pluripotent Stem Cells and supportive therapies (including hyperbaric oxygen chamber, Cryotherapy, Ozone therapy, Bioresonance, Detoxing and IV Vitamin therapy), showed visible signs of improvement in the following areas. Since Parkinson’s disease can only be diagnosed, when it affects about 60 percent of the nervous system, preventive strategies are not possible. Many of these nerve cells produce dopamine, a chemical messenger in the brain. Without them, the party is over and the cell dies. Another company developing a PARKIN-focused approach is a Korean company called Cellivery. Gene therapy involves treating medical conditions with DNA rather than drugs. This post is very quickly starting to feel like a never ending shopping list of clinical trials. And now, we move on to 2020 clinical trials involving the third component of any ‘curative therapy’ for Parkinson’s: Once the condition has been slowed/halted (#1) and a neuroprotective/nurturing environment is in place to protect the remaining cells (#2), a curative treatment for Parkinson’s will require replacing some of the cells that have been lost. In 2020, we will also be looking for news from a biotech firm called Prevail Therapeutics. The first of them is being conducted in Israel and involves 100 participants who have been evaluated for 6 months in a open label fashion (Click here to read more about this trial). As you shall see below, there are numerous clinical trials currently testing different therapies targeting different aspects of the autophagy process. One additional autophagy-related biotech company worth watching in 2020 is Samsara Therapeutics. This study is expected to finish in early 2021. At the start of year two, members of the placebo group will switch to receive BIIB054 treatment as well. Nature, 2020; 582 (7813): ... (2020, June 25). Ongentys, an add-on treatment for patients with Parkinson's disease, is entering the market soon. This post has been produced for educational purposes only. But now it’s time to give the fingers (and brain) a wee rest. ESB1609 is a novel, orally administered, brain-penetrant, selective sphingosine 1-phosphate 5 (S1P5) receptor agonist. Any actions taken by the reader based on reading this material is the sole responsibility of the reader. This study has been conducted by the biotech firm, Yet another company that recently announced a positive result in ALS is, This was a Phase I open label clinical study testing whether young plasma infusions could be safely used on 15 people with Parkinson’s. This study is scheduled to finish in 2021 (Click here to read more about this study). In the case of Parkinson’s, this approach is primarily being focused on different forms of alpha synuclein. HTTC Medical Group recognised the need for Biological Medicine, H. yperbaric Oxygen Therapy, Ozone Therapy and Cryotherapy services in Cyprus. Other clinical trials using c-Abl inhibitors specifically designed for neurological conditions (discussed immediately below) will be better tests of this class of drug for Parkinson’s. It promotes the clearance of mucus and eases coughing. Deepak – the Fujifilm video is a great find. In this randomised, double blind study, two doses of Ambroxol were tested – a high dose (1050 mg) and a low dose (525 mg) – as well as a placebo treated group. They are clinically testing a small molecule inhibitor of alpha synuclein called NPT520-34. Part 1 is a randomised, double-blind, placebo-controlled, three-arm study which will enrol approximately 300 people with Parkinson’s (all less than 2 years since diagnosis) to evaluate the efficacy and safety of RO7046015 in people with Parkinson’s over 52 weeks. The second technique involves administering Stem Cells via intravenous insertion. A second Chinese cell transplantation trial is also registered, and being conducted at The First People’s Hospital of Yunnan Province. Any actions being contemplated by readers should firstly be discussed with a qualified healthcare professional who is aware of your medical history. Started in early 2019, following the publication of a research report (Click here to read that report), Samsara is working with an autophagy-stimulating Japanese herb called ashitaba that is consumed on the island of Okinawa. We will learn more about the details of the “AZA-PD” trial early in 2020 (Click here to read more about this trial). Participants recieved 4 twice-per-week infusions of 1 unit of young plasma (from males ages between 18-25) and were then monitored over 8 weeks, Ceftriaxone is a cephalosporin antibiotic, which has been reported to have beneficial effects in models of Parkinson’s (, It is very important for all readers of this post to appreciate that cell transplantation for Parkinson’s is still. Thus, an important part of this new trial will be trying to identify characteristics of those who do respond compared to those who do not – which could aid in future administration of the drug (if it is eventually approved). Here at Poseidonia Healthcare, we offer a full range of treatments for Parkinsons Disease, here are a few benefits of the more popular treatments: Our Pluripotent Stem Cell Therapy can be administered in one of two ways. But the researchers then conducted a drug screen and identified a small molecule that promotes Miro1 degradation, and they found that this drug could rescue mulitple Parkinson’s models (Click here to read a previous SoPD post on the topic). Another form of ‘neuroprotective’ treatment that has been tested in Parkinson’s for a long time is neurotrophic factors. When performed in combination with your treatments, these therapies might improve your quality of life: 1. It is very important for all readers of this post to appreciate that cell transplantation for Parkinson’s is still extremely experimental. Feb. 27 (UPI) --Researchers have developed a new drug that could correct damage to the brain caused by Parkinson's disease and lead to improvement … This study is taking the new approach to cell transplantation, and the company is using a different type of stem cell to produce dopamine neurons for transplantion in the Parkinsonian brain (Click here and here to read previous posts about this). In addition, this may vary between individuals. Another biotech firm developing a small molecule to target alpha synuclein is NeuaroPore Therapies. Poseidonia Healthcare can offer both of these amazing treatments combined for Parkinson’s patients to give them the best chance of regaining some quality of life that they have lost. Thanks for sharing. As you can see in the images below, there is less dopamine being processed (indicated in red) in the putamen of the Parkinsonian brain on the left than the brain on the right (several years after bi-lateral – both sides of the brain – transplants): Brain imaging of dopamine processing before and after transplantation. This biotech firm is developing a drug that aims to increase the activity of active-form the Parkinson’s-associated protein PINK1. Once mature, however, it has also been demonstrated (using brain imaging techniques) that these transplanted cells can produce dopamine. Leading the pack in the race to develop LRRK2 inhibitors is a biotech firm called Denali Therapeutics. Also note that there another company called Anavex Life Sciences (AVXL) that is targeting various Central Nervous System Diseases (AD, PD, Rett, FTD ). 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